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ANNO·​TRICESIMO·​DIE·​DVCENTESIMO·​SEXAGESIMO·​SEPTIMO·​VITÆ·​POVYA
Dunning-KrugerAndTheGraphTheories
Dunning-Kruger And The Graph Theories
TalkingWithGPT
Talking With GPT
WhatATrulyRefinedSystemofThinkingInDynamicMediaWouldLookLikeWiththeEssenceofOurWork
What A Truly Refined System of Thinking In Dynamic Media Would Look Like With the Essence of Our Work
Quotes & Excerpts

Until recently we accepted that aging of cells was due to “wear and tear” like rusting out a car. The idea that accumulated damage is the principal pathway for cell aging is now complemented by the loss of cell identity model.

In embryonic and early development, our cells establish an identity. It’s locked in throughout our lives, except when it’s lost during the aging process. Although the DNA of every cell of our body is the same (or very close, if interested, see), the epigenetic structure, that includes methylation side chains, histones, nucleosomes and chromatin, is 3-dimensional and differs as a function of cell type. This is happening in the cell’s “mission control,” the nucleus. The epigenetic structure is the bedrock for our cell-specific identity.

There’s a 3-tier regulatory “grammar” that maintains the cell identity, […] The fast layer responds to acute stress in a matter of minutes to hours and relies on production of transcription factors, like AP-1. The intermediate layer takes days to weeks to respond, going through cell state transitions such as activating a cell to promote healing and return to its basal state. The key is the slow layer, he one that locks and insulates the cell identity, the hard boundary, relying on chromatin architecture.

That gets us to Waddington’s epigenetic landscape model for how cells differentiate or de-differentiate, a model that has held up well from Conrad Waddington in 1957! A cell sitting down in the valley (Figure below, culled together from the Nature paper) represents a distinct specialized cell. The deep slope indicates the robustness, also called canalization, accompanied by a deep basin, maintains the identity of the cell, promotes its stability. The differentiated cell is “staying in its lane” in the landscape model and is constrained from sliding out, shifting identity. But with aging, the valleys lose their slope, the basin becomes shallow, there is loss of epigenetic constraints, and there is instability of cell identity. That sets up drift of cell identity, or what can be regarded as mesenchymal drift.

Over the lifespan, as shown on the right side of the Figure below, after peak maturation with the specialized cells (brain, liver heart,kidney, etc) fully and irrevocably differentiated (peak functional state below), the valleys are losing slope and the basins are progressively getting shallower, known as decanalization. The problem is that there is no evolutionary pressure to keep the grooves, valleys and basin in their youthful state, because the “selection shadow” is a post-reproductive trajectory.

I hope your prints arrived safe. I was in a perfect whirlwind of dust & confusion, when I sent them off, else I should have written with the box.— The Canary scheme goes on very prosperously. I am working like a tiger for it, at present Spanish & Geology, the former I find as intensely stupid, as the latter most interesting. I am trying to make a map of Shrops: but dont find it so easy as I expected.—

MAESTRO DARWIN

I rather think we shall send him to Bruce C. School.—2 Your own system of Education sounds capital, & why you sh_ould_. Think I sh_ould_. Laugh at it, I cannot conceive: I believe a good deal of diversity an immense advantage. It is one good point at Bruce Castle: that no one subject exceeds an hour & if a Boy can do it quicker, he may go out before the hour is over.

I beg many pardons for my stupidity in having put wrong note in envelope.

Shall you be at Epperstone in the Autumn, & if you are, would be convenient, if I could manage to pay you a visit—answer this sincerely.— Cannot you pay me a visit at Shrewsbury, is it impossible?

MAESTRO DARWIN
Day's Context
Open Books
Dua Lipa versus the literary landscape Elise Trouw Breaks Down “How To Get What You Want” Elise Trouw uses Cympad Faber-Castell Perfect Pencil $275 vs $15 Comparison The Most Hated Designer of the 20th Century The “Perfect” Pencil? You decide! ✏️ What's the Difference? (Pelikan Souverän Explained) Counterblast
Written byMaestro McLuhan
&Harley Parker
Creative SchoolsThe Grassroots Revolution That's Transforming Education
Written byKen Robinson
&Lou Aronica
Leonardo Da Vinci
Written byWalter Isaacson
Project Management for DummiesSecond Edition
Written byNick Graham
RachmaninoffComposer, Pianist, Conductor
Written byBarrie Martyn
Year 30, day 267 of Pouya's Life Kary MechanicsThe overarching physics of mind, media, and communication. It posits that all ideas are defined by other ideas, forming a vast, high-dimensional graph that shapes human cognition and culture. 30⟡267Dunning-Kruger And The Graph TheoriesDefines Graph Zooming 30⟡267Dunning-Kruger And The Graph TheoriesDefines Graph Zooming 30⟡267Dunning-Kruger And The Graph TheoriesDefines Graph Zooming 30⟡267Dunning-Kruger And The Graph TheoriesDefines Graph Zooming 30⟡267Dunning-Kruger And The Graph TheoriesDefines Graph Zooming Sub-Graph TransferThe fundamental mechanism of communication. A sender transmits a partial graph (a scaffold of nodes), and the receiver reconstructs it using their own Mind Graph, actively filling the gaps. Mind GraphThe internal, weighted network of concepts, memories, tools, and emotions unique to an individual. The fundamental structure of the mind. 30⟡255A Whole Different Idea for the Future of Software Programming that Might be a Rediscovery of EveDefines Inconspicuous FoundationA foundational concept or tool that is so deeply integrated into the sender's Mind Graph that it is omitted during Sub-Graph Transfer, rendering the transmitted new nodes incomprehensible to the receiver. Mind GraphThe internal, weighted network of concepts, memories, tools, and emotions unique to an individual. The fundamental structure of the mind. Zeynab AkbariKnown as Zea Ashkan Bonakdar ShiraziKnown as Ashkan Isaac Newton 30⟡72Duck Protocol: Hidden mind kernel of The Human MindDefines Mind KernelThe unique generative algorithm or "source code" of an individual's Mind Graph. It dictates how a person processes inputs, forms connections, and creates outputs. 29⟡93Threshold of The Reverse ViewpointThe pivotal moment when an improvement to a tool or medium fundamentally alters its purpose, causing a paradigm shift where the old use becomes obsolete or reversed (e.g., email evolving from a faster fax to real-time messaging). Mind GraphThe internal, weighted network of concepts, memories, tools, and emotions unique to an individual. The fundamental structure of the mind. 30⟡69The Hyper-MessageDefines Hyper-MessageThe immense, global shared "dream" constructed by humanity's collective communication and Cultural Graphs. It shapes our perception of reality, often blinding us to alternative truths or the raw realities of the world (e.g., the reality of animal suffering). 30⟡69The Hyper-MessageDefines Hyper-MessageThe immense, global shared "dream" constructed by humanity's collective communication and Cultural Graphs. It shapes our perception of reality, often blinding us to alternative truths or the raw realities of the world (e.g., the reality of animal suffering). 30⟡69The Hyper-MessageDefines Hyper-MessageThe immense, global shared "dream" constructed by humanity's collective communication and Cultural Graphs. It shapes our perception of reality, often blinding us to alternative truths or the raw realities of the world (e.g., the reality of animal suffering). Stephen WolframKnown as Maestro Wolfram Archive